Purpose of running this test:
Looking at the Hair Elements Analysis (HMT) to determine the toxic and essential element content of your body is something like looking at the rings on a cross section of a tree. It gives you a longer term, more historical view of the toxic and essential metals in your body. The urine test, on the other hand, gives you a measurement of what is being excreted on the day the test was taken, the level of excretion for that day. It is useful to run the Urine Toxic Metals and Urine Essential Elements Test (UTM/UEE) at the same time as a HMT, at least initially, to get a baseline level of metals from both the immediate as well as the historic vantage point.
When detox is suspected because of behavioral changes or other issues in a child, or symptoms characteristic of detox in an adult, it is useful to have immediate feedback from a UTM/UEE or Fecal Metals Test (FMT), rather than waiting until the toxins causing the disturbance become evident in a hair sample. Environmental toxins are a risk factor in multi-factorial conditions, including the many adult and pediatric chronic illnesses evident at present. Urine toxic metal excretion data is also useful because the environmental toxic load in your body impacts your capacity to produce methyl groups and methylate appropriately. Impaired capacity to methylate affects multiple systems’ function, not the least of which are your immune and nervous systems. Additionally, methyl groups are important epigenetic regulators of genetic function, so impaired methylation has a global impact. See the Feel Good Nutrigenomics book for a more comprehensive discussion of epigenetics.
This urine test is particularly useful for looking at cobalt levels as a measure of B12 status secondary to methylation cycle support. Lithium is reported to impact B12 transport into the cell. Comparing data on lithium levels in urine as opposed to hair helps to determine how your body is handling this important trace element, and in so doing helps you to support the methylation cycle optimally.
The current financial climate has impacted the testing I ask for, however, I really like to see an initial UTM/UEE along with a HMT to get a baseline sense of toxic and essential minerals. Then, over time, the UTM/UEE can be rotated with a FMT and a HMT, so that one test is run every two or three months. In this way, over the course of a year, two of each of these tests is run. This gives me a sense of what is being excreted via all three routes, as well as a measure of essential elements.
If a certain essential element is particularly low, for example cobalt, or its excretion is particularly high, for example lithium, then running a HMT along with a UTM/UEE more often is worth considering, at least until you are certain that these critical minerals are in balance.
|TOXIC METALS||This table contains the rationale behind my suggestions. These suggestions are for your consideration. Defer your choices to your own health care practitioner, as always.|
|Aluminum||Aluminum can impact the Krebs energy cycle, so consider a Metabolic Analysis Profile (MAP test) if high levels are seen on a HMT. Also, aluminum can negatively impact tetrahydrobiopterin (BH4) levels, which in turn affects dopamine, serotonin and melatonin levels. A Neopterin / Biopterin Profile Urine Test can be run to help evaluate BH4 levels. Consider adding MetalAway, or selenium, horsetail grass, low dose EDTA, and malic acid. Also, you can use additional EDTA and EDTA soap or soak as tolerated. If you do not have shellfish allergies, consider using BactiSolve. Use MTHFR A1298C Liver Support capsules and/or BH4 to help support BH4 levels. Consider Vitamin E succinate if succinate levels are low on the MAP test. You can also run a UAA test to look at phenylalanine, tyrosine, and tryptophan levels as another means to determine the need to consider BH4 support.|
|Antimony||Antimony can bind to ‘thiol’, which means SH groups, which are needed to help escort mercury from your system. Also, antimony may inhibit the MAO enzymes, which may interfere with the natural breakdown of dopamine and serotonin. Antimony can accumulate in your adrenals and thus play a role in fatigue. Consider adding sources of ‘thiol’ groups, such as Selenium, MetalAway, or DetoxAway. Consider low dose Wasabi, low dose Selenocysteine, and/or low dose Ion Transport compound, which has both Wasabi and Selenocysteine. Broccoli and Garlic are also options. Also, consider OraAdrenal for adrenal support.|
|Arsenic||Methylation cycle function is needed for arsenic excretion. If arsenic is consistently high, consider running a Water Elements Test. Arsenic can bind both to thiol, which are SH groups, as well as phosphate groups. It may cause vitamin A deficiency. Symptoms of arsenic toxicity can include white streaked nails, a garlic odor emanating from your body, and/or under pigmentation. Arsenic toxicity may also cause hair loss, problems with folate uptake, or weakness, among other symptoms. At the very least, consider short cut methylation support, support for the pathway that goes from homocysteine to methionine using the BHMT enzyme. All in One, Phosphatidyl Serine Complex (PS/PE/PC), DHA and Methylation Support nucleotide blend all support the short cut. If lithium is in balance, also support the long route, the route that uses the MTR and MTRR enzymes. These supports include low dose Methylmate A, Methylmate B, and B12. Also, thiol supports may be useful, such as Selenium, MetalAway, or DetoxAway; low dose Wasabi, low dose Selenocysteine, or low dose Ion Transport compound, which has both Wasabi and Selenocysteine. Broccoli may also be helpful. To support phosphate, use phospholipids such as Phosphatidyl Serine Complex (PS/PE/PC) and Riboflavin-5-Phosphate, MitoForce or ATP.|
|Barium||Barium can displace potassium, and may cause an increase in stress hormones. It may also cause tingling and weakness of muscles. Consider potassium support with Potassium Citrate. If Krebs intermediates are low on a MAP test, then consider Krebs Magnesium-Potassium Chelates. If gut pH is very low then consider Potassium Bicarbonate. Also, Stress Foundation nucleotide blend and low dose Muscle Support nucleotide blend may be a help. In addition, Padma Basic may help with weak muscles and ginkgo along with Padma Basic if restless leg syndrome if they are issues.|
|Beryllium||High levels of beryllium may affect lymphocyte proliferation and respiratory function, as well as cause adrenal insufficiency and fatigue. Consider T cell and B cell support capsules for immune support. OraAdrenal may also be used for additional support. The Muscle Fatigue Support compound supplement can be considered if fatigue is an issue. Low dose Respiratory Support nucleotide blend may also be helpful.|
|Bismuth||High level excretion of bismuth, in the absence of any bismuth supplementation, may be an indicator for H. pylori, so testing to rule out H. pylori should be considered. Since high level bismuth excretion in the absence of any support can lead to depletion of bismuth over time, consider low level bismuth support with Peptimycin or its equivalent. Rule out H. pylori.|
|Cadmium||High levels of cadmium can cause significant symptoms. Your body uses zinc as a cofactor for over 50 critical enzymes. However, if zinc is deficient, your body will replace it with cadmium. Cadmium is just below zinc in the periodic table, so it fits perfectly into zinc binding sites. Enzymes that make protein, such as RNA transferase, and alcohol dehydrogenase, the enzyme involved in alcohol processing, are impacted by this problem. Other important enzymes are also negatively impacted. Cadmium may also bind to glutathione (GSH) making it ineffective. It may also negatively impact bone health and cause respiratory symptoms. Consider supporting with Zinc Lozenges, or Krebs Zinc, if your Krebs intermediates are low on a MAP test. Also, consider MetalAway and/or EDTA to help escort cadmium from your system. Since cadmium can bind GSH, consider supporting with GSH. Low dose Bone Support nucleotide blend may also be helpful. Cadmium may decrease the Cytochrome P450 enzyme system, so consider I-3-C Plus (Indole-3-Carbinol and DIM) capsules to support CYP 450. Since cadmium replaces zinc in arteries, adults may want to consider low dose Heart Support nucleotide blend and Hawthorn Extract. Also, consider Vitamin E and low dose Ion Transport support capsules for cadmium, as it may help prevent the cadmium induced suppression of the CFTR enzyme. Also, work on supporting methylation, as weak methylation capacity is related to susceptibility to cadmium. In addition, lithium, which is in both BeCalm Spray and All in One, may help to protect against the negative impacts of cadmium, especially with respect to hormones such as testosterone, LH, and FSH.|
|Cesium||Cesium inhibits potassium currents, so it can cause fatigue and palpitations, as well as muscle weakness. Use a form of potassium support that compliments your other biochemistry, ie, Potassium Citrate, Krebs Magnesium-Potassium Chelates, or Potassium Bicarbonate can be considered depending on other test values, such as a MAP test for Krebs minerals or pH levels in the gut may indicate Potassium Bicarbonate. Consider low dose Muscle Support nucleotide blend, and, if needed, Muscle Fatigue Support compound supplement.|
|Gadolinium||Gadolinium is a contrast dye used for MRIs. High levels in your system may cause kidney problems, skin rashes, and joint and muscle weakness. While gadolinium does not always cause these problems, if high levels of this mineral are excreted, consider support for your organ systems. Consider T cell and B cell support capsules for immune support. In addition, MTHFR A1298C Liver Support capsules, Gymnema, Ora-Kidney, Ora-Liv, Kidney Support nucleotide blend, Liver Support nucleotide blend, and I-3-C Plus (Indole-3-Carbinol and DIM) capsules can all be considered to support other organ systems.|
|Lead||Lead can deposit in bone and replace calcium there. Lead can also affect ATPase, which reduces the production of this energy molecule. This negatively impacts both sodium and potassium levels, as well as energy production. Lead can bind melatonin, tryptophan, and serotonin. Consider a MAP test and a Neurotransmitter Urine Test to look at energy markers, as well as neurotransmitter levels. Lead excretion can cause pica, teeth/jaw grinding & aggression. Eating inedible objects may be a sign that lead is being excreted. You may want to consider support to help escort it from your system. Elevated 5-amino levulinic acid (ALA) due to lead toxicity can inhibit Gamma amino butyric acid (GABA), so consider extra GABA if needed. Since lead replaces calcium in bones, consider low dose Bone Support nucleotide blend. Vitamin D and K impact calcium absorption, so consider a mineral combination that includes vitamin D and K, such as Cal/Mag/VitD/VitK. Also, for bone health, watch strontium and boron levels. Consider MTR/MTRR/SUOX capsules to support strontium and boron. Also, consider EDTA and MetalAway (or selenium + horsetail grass + low dose EDTA + malic acid) to help escort lead from your system. Also, consider additional EDTA in EDTA soap or soak as tolerated. Consider using BactiSolve if you have no shellfish allergies, as another source of EDTA. Consider ATP and/or MitoForce to support ATPase.|
|Mercury||In addition to a wide range of neurological symptoms, mercury can also cause increased salivation, rashes, and metallic taste in your mouth. It can impact cytochrome P450, and may replace selenium in the T4 to T3 reaction, thus causing thyroid hormone imbalances. Consider support with Selenium or MetalAway. If more detox is desired, consider DetoxAway. Also, GSH and I-3-C Plus (Indole-3-Carbinol and DIM) capsules may be used. Ultimately, you can support re-myelination with Sphingolin. Work on methylation cycle support to help allow the natural detox of mercury. Also, the consider low dose Ion Transport compound as it may help support detox because it contains Selenocysteine and Wasabi to aid in escorting mercury from your system. Basic methylation support includes All in One, Phosphatidyl Serine Complex (PS/PE/PC), DHA and Methylation Support nucleotide blend. Once lithium is shown to be in balance on a HMT, then consider low dose Methylmate A and Methylmate B, along with extra B12.|
|Nickel||Nickel can cause significant skin rashes, allergies, dermatitis and inflammation. Consider Riboflavin-5-Phosphate, especially when phosphorus is low and nickel toxicity is present. Consider nucleotide blends such as General Support nucleotide blend and Cytokine Balance nucleotide blend to help with itching. Clear Skin spray may be used for topical skin support.|
|Palladium||Palladium may impact your liver and kidneys. It can cause free radical damage to DNA, and allergic reactions, especially for those with nickel allergies. Consider Kidney Support nucleotide blend, Liver Support nucleotide blend, Ora-Kidney, Ora-Liv and/or MTHFR A1298C Liver Support capsules. Consider Riboflavin-5-Phosphate to help with nickel, Quercetin in low doses if COMT status is not an issue, and General Support nucleotide blend. You can also consider an Oxidative Damage test to assess damage.|
|Platinum||Platinum can cause wheezing, excessive mucous in your nose, and dermatitis. Consider Zinc Lozenges and low dose Respiratory Support nucleotide blend. Also, Serraflazyme and Air Power may help with mucous, along with Muscle Fatigue Support compound.|
|Tellurium||Tellurium is chemically similar to selenium, so consider extra selenium support when tellurium levels are high. Some options include MetalAway, low dose Selenocysteine, low dose Ion Transport compound or other low dose forms of selenium.|
|Thallium||Thallium inhibits mitochondrial energy and ATP. It also inhibits DNA and RNA synthesis. It may cause hair loss and anorexia. Thallium can also cause riboflavin to be sequestered in the body. So Riboflavin-5-Phosphate support should be considered, especially if MAP test results show imbalances in the Krebs energy cycle. Consider support with ATP, Riboflavin-5-Phosphate, and/or MitoForce to address the impact on energy. Also, All in One for low dose DNA and RNA support, and AHCY/SHMT compound, or direct addition of nucleotides.|
|Thorium||Thorium can bind to digestive enzymes. Consider Special Digestive Enzymes, and run the CSA test and GI360 Test (CPG) to check on digestion.|
|Tin||Tin may cause liver pain, and may be more of an issue if your system tends to be acidic. Check your pH on a CSA test or GI360 Test (CPG), and/or use pH strips on first morning urine samples. Work to get pH to around 7 with Buffer pH, VitaOrgan, and/or Stomach pH Balancing nucleotide blend. If your potassium is low, then consider Potassium Bicarbonate. Also, consider I-3-C Plus (Indole-3-Carbinol and DIM) capsules to support cytochrome P450 enzymes that may be decreased due to tin and consider Special Digestive Enzymes. MTHFR A1298C Liver Support capsules, and low dose Liver Support nucleotide blend can be considered for liver support.|
|Tungsten||Tungsten interferes with molybdenum, may cause DNA damage, and may be a factor in impaired sense of smell. Tungsten can interfere with SUOX, so consider B12, provided that lithium is in balance. Also, watch levels of molybdenum, boron, and manganese. Provided that lithium is in balance, consider support with B12 formulas like Hydroxy B12 spray, Methyl B12 MegaDrops, Hydroxy B12 MegaDrops, or Adenosyl B12 MegaDrops. Consider MTR/MTRR/SUOX capsules to help support molybdenum, boron and manganese. Consider a DNA oxidation test, and if DNA damage/oxidation is a concern, then consider Ultifend and/or Quercetin. High dose quercetin may be an issue for those who are COMT ++.|
|Uranium||Uranium can readily combine with nucleotides in your body and can deposit in your bones. It can also cause chronic fatigue. Test your home water supply with a Water Elements Test, and do a radon air test if you continue to excrete high levels of uranium over time. Consider All in One for low dose nucleotide support. Use AHCY/SHMT compound for nucleotide support, or direct nucleotide supplementation. Consider using Muscle Fatigue Support compound and low dose Bone Support nucleotide blend. Consider Cal/Mag/VitD/VitK so that vitamin D and K are present to help with calcium absorption. To support your DNA in the presence of high levels of uranium, also consider Ultifend and Quercetin.|
|Creatinine||A high level of creatinine means that your urine is very concentrated. This may indicate that your kidneys are under stress. For this issue, consider Kidney Support nucleotide blend, Ora-Kidney, Dandelion Leaf, Rhodiola, SHMT Spray, AHCY/SHMT compound, and Zinc Lozenges. If your pH is low, consider using sodium bicarbonate to both help with pH as well as to help with high creatinine. If your creatinine is chronically high, also check your blood sugar levels. Creatinine levels that are low suggest insufficient methylation and a need for SAM-e. Low levels of creatine have been associated with limited language development. You can consider using Creatine plus SAM-e. Basic methylation support includes All in One, Phosphatidyl Serine Complex (PS/PE/PC), DHA and Methylation Support nucleotide blend. Once lithium is shown to be in balance on a HMT, then consider low dose Methylmate A and Methylmate B, along with extra B12.|
|ESSENTIAL ELEMENTS||This table contains the rationale behind my suggestions. These suggestions are for your consideration. Defer your choices to your own health care practitioner, as always.|
|Sodium||Your goal is to keep sodium in the normal range, without its being too low or excreted to a high degree. The use of Ion Transport compound and low dose Ion Transport Support nucleotide blend may be a help. Sodium is co-absorbed with a range of other nutrients, such as amino acids, glucose and peptides, so supporting healthy ion transport can be useful. Since sodium and potassium transport across your cell membrane uses energy, consider ATP, Riboflavin-5-Phosphate, and/or MitoForce to support sodium/potassium ATPase. Also, consider using low dose Ion Transport compound and low dose Ion Transport Support nucleotide blend. In addition, the use of Sodium or Potassium Bicarbonate may be considered if your pH is low on a CSA test or GI360 Test (CPG), as a way to support both sodium and a more balanced pH.|
Potassium levels drop coordinately with low lithium, so support potassium when you are taking lithium. Low potassium can cause rubidium levels to drop. Your body replaces potassium with rubidium when potassium is deficient. This can create a rubidium deficit, which is a factor in aggressive behavior. The approach this program uses is to consider support with potassium for either low potassium or low rubidium. Potassium levels that are less than 50ppm or 5%, may indicate copper toxicity. Barium and cesium may displace or interfere with potassium function. Additional potassium support may be needed if you have high levels of barium or cesium excretion.Also, low levels of potassium may be caused by hydrogen sulfide (H2S) triggering efflux of potassium, so check sulfur levels on the HMT and UEE, as well as taurine levels on a UAA. High levels of taurine on a UAA may indicate higher than ideal H2S levels in your system, which can then cause low potassium levels.Low levels of potassium can be a factor in the production of acne.
Potassium Citrate can be used along with food sources of potassium to support potassium. If your pH is low on a CSA test or GI360 Test (CPG), then Potassium Bicarbonate can be considered to both support potassium and to help balance pH. If Krebs intermediates are low on a MAP test, consider Potassium Krebs Intermediates if you do not have glutamate/ GABA imbalance.
Arginine may have a positive impact on potassium levels. Those who struggle with consistently low potassium, especially athletes, may consider low dose Arginine support if your levels of arginine are low on a UAA test. AminoAssist is one source of low dose arginine.
|Phosphorus||If your phosphate is low, then your leucine may be high. According to published literature, if phosphate is low, then leucine may be increased, which in turn may increase glutamate and alpha KG. This can potentially cause hypoglycemia. Your level of leucine can be checked on a UAA. Consider phosphate support when phosphate is low, when hypoglycemia is an issue, when glutamate and leucine are high on a UAA test, or when alpha ketoglutarate is either very high or very low on a MAP test. Cross referencing between these tests is helpful when problem solving. Supplementing phosphorus may help with excessive dumping of calcium in your urine. Copper toxicity may be a factor when phosphorus is low. Check your copper levels.Riboflavin-5-Phosphate can help support phosphorus, especially if nickel toxicity is present. Also ATP and/or MitoForce may help to support phosphorus. Phospholipids such as Phosphatidyl Serine Complex (PS/PE/PC) and nucleic acids such as RNA can also support phosphorus. Vitamin D may help with phosphorus absorption. Pumpkin seeds are a natural source of phosphorus.|
Ideally, your test will show more magnesium relative to calcium. Excess calcium can work with glutamate to cause excitotoxicity, so high levels of calcium may cause symptoms if glutamate is also high. Your goal for calcium is to be in the low range of normal, with magnesium in the high range of normal. Since vitamin D and K help with calcium absorption, less calcium support may be needed if vitamin D and K are supplemented. Check to see if boron is being dumped, as boron is often dumped with low vitamin D. So, high level calcium and boron dumping may indicate a need for Vitamin D. If calcium is higher than 650ppm or 65%, it may indicate copper toxicity. There may be a greater need for calcium support with a high protein diet.Guaifenisen, which is used for chronic fatigue, may help pull down high calcium. Low dose support can be considered in the Muscle Fatigue Support compound, or in Air Power. Other supplements used to help control high calcium include Vinpocetine, Boswellia, ATP and/or MitoForce. These may support better calcium balance because they support mitochondrial function, and mitochondria may act as sinks to buffer the effects of calcium overload.
If calcium levels are too low, consider herbs that support calcium in a complexed form, such as Nettle, Chamomile, or Chervil. The use of Cal/Mag/VitD/VitK compound also supports calcium in a balanced fashion. Low calcium can play a role in back pain, menstrual cramps, and brittle nails.
Boron deficiency may cause dumping of calcium and magnesium in urine.
|Magnesium||Magnesium may be calming and have a positive impact if you have excess glutamate in your system. It is preferable to have higher magnesium relative to calcium in your body, because calcium works with glutamate to cause over excitation of nerves, and magnesium helps to balance this. Boron deficiency may cause dumping of calcium and magnesium in urine. Check boron to be sure that it is not causing low magnesium levels. Low taurine can cause magnesium dumping, so be sure methylation support is in place to support healthy taurine levels. You do not want very high taurine levels, nor do you want low levels. The goal is taurine in a normal range. This can be measured on a UAA test. Low dietary magnesium may contribute to aluminum-induced degenerative conditions. Consider support with Magnesium Citrate, Magnesium Oxide, or Magnesium Malate. Magnesium glycinate is non-optimal, as glycine can exacerbate glutamate toxicity if your levels of glutamate are high. Amino acid chelates of minerals are not always ideal, especially if you have symptoms of excitotoxicity, because they include glutamate and aspartate. I occasionally recommend them, and we do stock them, so just be aware of this when you are ordering minerals.Basic methylation support includes All in One, Phosphatidyl Serine Complex (PS/PE/PC), DHA and Methylation Support nucleotide blend. Once lithium is shown to be in balance on a HMT, then consider low dose Methylmate A, Methylmate B, and extra B12.|
As with magnesium, zinc helps to control the calcium and glutamate interaction that can lead to over excitation of nerves. Doses of zinc above 40 mg per day can actually stimulate excitotoxin activity, so your goal is to keep zinc in the high range of normal with under 40 mg of supplementation per day. A deficiency of zinc may cause poor wound healing, poor ability to smell or taste, and night blindness. Iron interferes with zinc absorption, so keeping iron in proper balance is an important factor in achieving proper zinc levels. When iron replaces zinc, it may cause blood sugar imbalances, so consider support for the pancreas and pancreatic enzymes when zinc is low. Your body uses zinc as a cofactor for over 50 critical enzymes. It prefers it. However, if zinc is deficient, your body will replace it with cadmium or lead, both of which are toxic metals. Cadmium is just below zinc in the periodic table of the elements, so it fits perfectly into zinc binding sites. Cadmium may replace zinc in enzymes that make important proteins, such as RNA transferase and alcohol dehydrogenase, the enzyme involved in alcohol processing. These enzymes do not function properly with cadmium replacing zinc. Cadmium may also replace zinc in metallothionein, an important heavy metal binding agent. When zinc is low, lead can replace zinc in heme enzymes and impact the formation of red blood cells. So it is important to keep zinc in the high normal range.Some studies suggest that low zinc may increase the activity of the enzyme methionine synthase (MTR). This could in turn lead to lower lithium levels and exacerbate MTR + status. Low dose methionine support, which is contained in AminoAssist, may be helpful in these cases.
Zinc Lozenges are the form of zinc that is particularly helpful and well absorbed. Consider Zinc Krebs Intermediates if your levels of Krebs intermediates are low on a MAP test, and you do not have symptoms of glutamate/ GABA imbalances.
If your iron is high on a HMT or UEE, consider AHCY/SHMT compound and/or Lactoferrin to help keep iron in better balance. Consider pancreatic support with VDR/FOK Pancreatic Support capsules, Ora-Pancreas, and/or Special Digestive Enzymes if your zinc is low and iron is high, to help with blood sugar balance.
When your zinc is low, consider Heart Support nucleotide blend and Hawthorn Extract if you are an adult. Cadmium can replace zinc in the atrial wall of your heart and may cause decreased flexibility and strength.
Coffee may impair zinc uptake and may lead to a need for increased zinc support.
Ideally, your copper levels should be lower than zinc to favor a higher zinc to copper ratio. High copper has been implicated in ADD. Copper is the cofactor that works with the enzymes MAO A and MAO B to break down dopamine and serotonin, so high copper may engender a higher degree of degradation of these two neurotransmitters. Running a Neurotransmitter Urine Test and a MAP test gives you an indication of both the levels of serotonin and dopamine, and a measure of their breakdown. Excess copper has also been reported to cause fearful thoughts. If copper replaces zinc in your brain, it may be a factor in migraines, so zinc support may help you with this, as well as bring your copper into better balance.Much less frequently, the issue is actually low copper. Low copper may cause high histamine. The enzyme that breaks down histamine is a copper containing MAO type of enzyme, so if your copper is low, check to see if your histamine is high. Quercetin may help pull down histamine but inhibits COMT, so use quercetin in moderation. A natural source of quercetin is cherries. Cherries are also a source of melatonin. Tart Cherry Extract is reported to be helpful for gout.
Low copper may also be a factor in de-pigmentation of hair and skin.
Ways to help bring copper into better balance include the use of Molybdenum, Zinc, Carnosine, and increased EDTA. EDTA is found in MetalAway, EDTA soap or soak, and DetoxAway. You can also consider BactiSolve if you have NO shellfish allergies.
Check molybdenum levels, because often copper will be high when molybdenum is too low. Molybdenum can be low due to high taurine, which is measured on a UAA test. When taurine is processed via sulfite oxidase, molybdenum can become depleted. In addition, high levels of sulfur can have the same effect of depleting molybdenum. Molybdenum may also be depleted due to chronic yeast infections, which can be checked on a Vaginosis Test, or in the gut via a CSA test or a GI360 Test (CPG).
An alkaline environment limits copper, so work to get pH in balance, meaning having a pH close to 7. You can consider Buffer pH, Stomach pH Balancing nucleotide blend, Potassium Bicarbonate or sodium bicarbonate, depending on your need for either sodium or potassium. VitaOrgan may also help to balance your pH.
|Sulfur||High levels of sulfur can put excessive stress on SUOX, the sulfite oxidase enzyme, which appears below the cystathionine beta synthase (CBS) enzyme in the transsulfuration pathway portion of the methylation cycle. The SUOX enzyme needs B12 and molybdenum for activity. So, high sulfur can result in increased usage of B12 and molybdenum that are needed for other functions in your body. Low molybdenum can mediate an increase in copper, and unbalance your zinc/copper ratio, which can then affect attention, reduce heavy metal detox, and cause other symptoms. Depletion of B12 can limit enzyme activity in the long route, the reaction in your methylation cycle that uses the MTR and MTRR enzymes. If your sulfur levels are high, consider using additional Molybdenum and B12 once your lithium is in balance on a HMT. You may also consider using Black Bear Spray or Black Bear Drink, which is a combination form of molybdenum and B12. Consider a UAA test to be sure that your taurine levels are not high, as high taurine would also put increased pressure on sulfite oxidase activity.For low levels of sulfur support, use healthy sulfur donors that have other positive attributes such as Garlic, Broccoli, Wasabi, SAM-e, or N-Acetyl Cysteine.|
Manganese is important for helping to process arginine, so consider supporting with low dose Manganese if arginine is high on a UAA test. However, high levels of manganese are a concern for the reasons described below. Ideally, your manganese levels are in the lower range of normal so that they are sufficient to support reactions that require manganese without allowing levels to climb too high. Proper manganese levels are important to preserve acetylcholine, an important neurotransmitter. Low manganese can also impair the function of your Krebs energy cycle. Low levels of manganese can cause hearing loss and low sex drive. Low manganese can cause low cholesterol, imbalances in alkaline phosphatase levels, and decreased T cells.Most bacteria use iron for growth, but Borrelia burgdorferi uses manganese, so low manganese may be seen in Lyme disease. Manganese levels may also drop with H. pylori infection. Consider ruling out H. pylori or Lyme disease if you have chronically low levels of manganese.
Iron can compete with manganese for uptake, so be sure iron is in balance.
To support low levels of manganese, consider MTR/MTRR/SUOX capsules, Manganese Drops, and Glucosamine/Chondroitin Plus. Consider T cell and B cell support capsules immune support. AHCY/SHMT compound or Lactoferrin may help to get iron in better balance.
Conversely, excessively high levels of manganese can cause psychosis as well as seizures. Excessive accumulation of manganese causes a neurological condition called “manganism” that is characterized by psychosis and eventually followed by symptoms similar to those seen in Parkinson’s disease. High levels of manganese have also been associated with ALS and biochemical changes similar to Alzheimer’s and Huntington’s disease (Sidoryk-Wegrzynowicz, 2013). High levels of manganese can cause increases in reactive oxygen species (so consider Ultifend), impair glutathione levels (consider GSH) and increase inflammatory mediators (consider General Support nucleotide blend and low dose TNF nucleotide blend). High dose manganese may also decrease dopamine levels.
Toxic doses of manganese can impact both GABA and taurine levels and affect their transport. If an individual is intolerant to GABA supplementation in spite of symptoms that suggest a need for GABA, then check manganese levels to be sure they are not exceedingly high. The use of valerian root in conjunction with low dose GABA may be a consideration for you and your doctor, as valerian may aid in GABA transport. If high manganese is the issue, consider increased EDTA support. Working with, and deferring to your own doctor consider the use of MetalAway, DetoxAway, EDTA soap and soak, and additional EDTA capsules can be considered.
If very high levels are seen, rule out high manganese in your home water supply by using the Water Elements Test. Some defective water filtration systems may be a source of higher than ideal levels of manganese in your drinking and bathing water supply.
|Molybdenum||Molybdenum is critical for sulfite oxidase function, the enzyme that processes sulfite to sulfate. Those who are sulfur sensitive should keep a close eye on molybdenum levels. Sulfite oxidase follows CBS in the methylation cycle, so excess CBS activity can put more pressure on sulfite oxidase and generate the need for molybdenum. Molybdenum is also needed to help keep copper in balance. High copper has a number of non-ideal effects, including allowing the increased breakdown of dopamine and serotonin. Molybdenum is also needed for xanthine oxidase function. Significant xanthine oxidase may be present in homogenized milk, so those drinking milk may have a need for molybdenum support. Those who have high levels of tungsten may need molybdenum support, as tungsten competes with molybdenum. In addition, those who are MTR + often show lower levels of molybdenum, so more frequent HMT and UEE can be run to be sure molybdenum stays in balance. Molybdenum can be supported with Molybdenum Capsules, MTR/MTRR/SUOX capsules, Black Bear Spray or Black Bear Drink. Molybdenum Drops can also be used, although the liquid form is complexed with ammonia so this is not the preferred form of support.|
|Boron||Low vitamin D levels may relate to low boron levels, so additional support may be needed in areas of low sunlight during the winter. Also those who are MTR + may tend to have lower boron levels. When boron is low, this deficiency may cause dumping of calcium and magnesium in urine. So check boron levels when there is high level excretion of magnesium and calcium in urine. Consider support with either Bone Support capsules or MTR/MTRR/SUOX capsules to help balance boron levels.|
|Chromium||Low levels of chromium can be factors in ADD and anxiety. Also low levels of chromium may be associated with blood sugar imbalances. Consider Chromium Picolinate support and VDR/FOK Pancreatic Support capsules.|
The role of lithium in B12 transport into the cell is potentially critically important. Peer reviewed work by Tisman, Herbert, and Rosenblatt published in the British Journal of Haematology was the first to illustrate that ingestion of lithium is related to B12 binding. Continuing this research, Vanyo and coworkers (Lithium in Biology and Medicine) discuss the finding that lack of lithium and B12 deficiency share physiological features, and that support with lithium enhances B12 transport into cells. According to these researchers, lithium is associated with elevated levels of serum B12 binding capacity. Furthermore, this group was able to show that lithium increases the transport of folate into the cell, as well as that of B12.
Additional peer reviewed work by Schrauzer (Biological Trace Element Research) also supports the role of lithium in B12 transport. The addition of lithium was shown by Cervantes et al to lower elevated serum B12 levels, again illustrating lithium’s effecting B12 transport into cells.
Based on this research, it is important to look at lithium levels. I use the HMT and the UTMEE in combination with each other to assess both lithium as well as cobalt levels (as a measure of B12). You may also want to look at serum lithium and B12. In cases in which lithium is low and/or serum B12 is particularly high, use lithium support prior to the addition of high dose B12. Lithium support is in All in One, Be Calm Spray, and Lithium Orotate.
Use these with the consent of your doctor. The rationale behind this is to ensure that you have adequate lithium prior to adding high dose B12, because increasing B12 in the absence of lithium support may further deplete lithium levels due to the use of lithium to aid in the transport of the added B12. Ideally, lithium should be in balance prior to adding excess B12 so as not to create lithium depletion. Low dose maintenance nutritional levels of lithium support are available in All in One and Be Calm Spray.
Lithium plays a range of additional roles in your body aside from B12 and folate transport into your cells, so it is important not to deplete this pivotal trace mineral. Lithium’s impact on mood stabilization has been known and used clinically for many years, despite the fact that the mechanism by which this occurs has not been fully elaborated. Norepinephrine imbalances have been implicated in attention disorders, and Sastre and coworkers have illustrated an impact of lithium on balancing norepinephrine levels.
Researchers have noted and published effects from lithium on neurological conditions. Beta amyloid may play a role in Alzheimers Disease and lithium has been shown to have neuroprotective effects against beta amyloid. Research from Spain illustrates that lithium has a positive impact on neural repair after traumatic injury. Maurer (2009) showed that lithium can enable mitochondrial function, which may be particularly useful in the presence of toxic metals. Increases in the grey matter of the brain have been tied to lithium support (Moore) and research from the National Institute of Health (NIH) showed the induction of brain derived neurotrophic factor (BDNF) by lithium. Especially relevant to this program, lithium was reported by Hashimoto (2002) to protect against glutamate excitotoxity.
In addition, lithium has been implicated in Lyme disease, as well as having an impact on Herpes virus (Amsterdam et al).
Lithium may also help to support healthy tetrahydrobiopterin (BH4) levels.
Lithium stimulates white cells and platelets, so low levels of lithium may cause low white cells. Myrrh may help for low white cells.
Those who are MTR + tend to have lower lithium levels.
For levels that are particularly low, consider Lithium Orotate plus some form of potassium, usually Potassium Citrate. Run regular HMT to assess lithium levels when adding lithium orotate. Those who are MTR + should do a HMT every 3 to 4 months.
High level excretion of lithium in the absence of any lithium supplementation suggests that excretion will lead to future depletion. Thus, lithium should be added when lithium is either very low, or when high level excretion is seen in the absence of any lithium supplementation.
Low lithium may also be an issue secondary to a need for mitochondrial energy support. A MAP test can be run to look at energy markers. Support for mitochondrial energy can include MitoForce, ATP, Riboflavin-5-Phosphate, NADH, Krebs minerals.
|Selenium||Selenium may become depleted with high level mercury excretion, as well as with the excretion of a number of other toxic metals. Consider extra selenium support when toxic metal excretion is observed. If selenium levels are low on a HMT, use additional support. Selenium is essential for the conversion of T4 to T3, T3 being the active form of thyroid hormone. The de-iodinase enzymes that remove iodine atoms from T4 during its conversion to T3 are selenium-dependent. So, consider selenium when you have low thyroid symptoms. PABA, found in Ultimate B, and Niacinamide can be considered for those who have indications of autoimmune thyroid issues. Very high levels of selenium are toxic, so the goal is to be within normal range for this mineral. Methylation cycle function is needed to remove excess selenium, so until methylation support is in place, and you know you have good methylation pathway function, do not use high dose selenium. Consider support with MetalAway or other sources of Selenium. Consider low dose Ion Transport compound as a source of selenocystene, or low dose Selenocysteine. GSH and Vitamin E succinate may aid in maintaining selenium levels. Excretion of mercury, antimony, arsenic, and/or thorium may lead to a greater need for selenium support. DetoxAway can be considered for higher dose support during detox once effective methylation support is in place. As always, work with your doctor.Basic methylation support includes All in One, Phosphatidyl Serine Complex (PS/PE/PC), DHA and Methylation Support nucleotide blend. Once lithium is shown to be in balance on a HMT, then add low dose Methylmate A, Methylmate B, and extra B12 in the appropriate form.|
|Strontium||Strontium levels tend to be lower for those who are MTR +. Consider MTR/MTRR/SUOX capsules if your strontium is low, or being excreted excessively in the face of no supplementation.|
|Vanadium||High levels of vanadium may be related to bipolar. Low levels may be an issue for blood sugar balance. Vanadium can bind to iron complexes, so be sure iron is in balance. Consider vanadyl sulfate (depending on sulfur levels) and VDR/FOK Pancreatic Support capsules for low vanadium. Also, you can use AHCY/SHMT compound or Lactoferrin to help with iron balance.|
|Cobalt||All forms of B12, hydroxyl, adenosyl, methyl, and cyano, contain the element cobalt. It is possible to follow cobalt levels on a HMT and UEE as a method for tracking B12 ingestion. Blood B12 levels can also be directly measured. Be sure lithium is in balance before adding high dose B12. As you increase B12 support, follow with HMT testing to be sure lithium stays in balance. There are several forms of B12. Hydroxy B12 is usually well tolerated and is used by everyone on this protocol. Adenosyl B12 is also usually well tolerated. It is often a help for high methylmalonic acid (MMA) levels on a MAP test, as well as to help process fats when used in conjunction with Biotin. MethylB12 may be tolerated by those who are COMT – and some who are COMT + -. It is used in limited ways in my protocol.|
Excess iron is pro-oxidant and drives bacterial virulence, so high iron on this test may indicate issues with bacterial imbalances. If your iron is above the 50th percentile, consider a CSA test and GI360 Test (CPG) to check for unbalanced, non-optimal organisms in your gut. Adult females may want to run a Vaginosis Test in addition, to check for bacteria and yeast. Iron helps to increase SHMT activity, which diverts methylation intermediates from both the MTR/MTRR enzyme reaction, what I call the long route around the methylation pathway, and the BHMT enzyme reaction, the short cut. Limiting iron is particularly important for those who are SHMT +. Iron can bind tryptophan, so it may reduce serotonin levels.H2S frees up iron, so check taurine and sulfur levels. If taurine and sulfur are high, then consider that excess iron may be an issue.
Levels of iron are increased with humic acid, which is in part why humic acid is not a part of this program. Humic acid may cause lipid peroxidation.
High iron levels may be related to high methionine, so if your methionine is high on a UAA test, check your iron levels.
Lactoferrin and/or AHCY/SHMT compound may help bind and transport iron to where it is needed in your body. Also, if your iron is high, work to shift acidic environments to alkaline environments, because acid increases iron. So, consider Buffer pH, VitaOrgan, and/or Stomach pH Balancing nucleotide blend. Either sodium bicarbonate or Potassium Bicarbonate can be used to help balance pH depending on your need for sodium or potassium. Check pH on a CSA test, GI360 Test (CPG), or by testing urine with pH strips.
Also, consider VDR/FOK Pancreatic Support capsules, because iron can cause blood sugar issues when it replaces zinc.
If you need iron support, then complexed herbal forms may cause less excess iron in your system. Dandelion greens are an excellent source of iron that also may be supportive for your kidneys.
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Related Tests to Run
The Fecal Metals Test (FMT) and the Hair Elements Analysis (HMT) can be run along with the UTM/UEE to get a more complete picture of the toxic and essential minerals in your body. To save on costs, you can consider rotating the HMT with the FMT and the UTM/UEE so that one of these tests is run every 4 to 8 weeks depending on finances, the degree of your illness, and your need to assess the efficacy of your supplement regime in addressing your health concerns.