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Purpose of running this test:

The Bone Resorption Assay is useful for assessing the need for natural bone support compounds in older adults, as well as for those of you with high levels of toxic minerals in your body, especially lead and cadmium. Lead and cadmium impair the integrity of bones and may indicate the need for additional bone support for those with Ehlers Danlos Syndrome.

Bone resorption is related to the activity of enzymes that break down bone, as well as degrade collagen. These enzymes are called matrix metalloproteinases, abbreviated MMPs. As you age, the level of MMPs increases, which may be related to increased bone resorption. Studies have shown that decreasing the level of MMPs helps to limit some types of bone resorption. Therefore, the Bone Resorption Assay may relate to MMP levels. It is possible that this test indirectly indicates MMP activity.

Collagen is also broken down by MMPs. Ehlers Danlos Syndrome is a condition involving improper processing of collagen. It is possible that an increase in bone collagen peptides may be reflecting, in part, the activity of MMPs which are a factor in Ehlers Danlos, making this test potentially useful for those with this condition.

A recent review by Chopra, Baveja and Kuhad (2015) suggests that excess MMPs play a role in schizophrenia and brain inflammation.

Result This table contains the rationale behind my suggestions. These suggestions are for your consideration. Defer your choices to your own health care practitioner, as always.
High level of bone resorption Consider low dose Bone Support nucleotide blend, and Bone Support capsules. Depending on your level of calcium and magnesium on a HMT and UEE, you can consider the use of Cal/Mag/VitD/VitK supplement, in addition to the use of the Bone Support capsules. Recall that calcium needs vitamin K and vitamin D to be used effectively. Adding high doses of calcium in the absence of vitamins D and K may not only be less effective, but also may increase excitotoxin activity. Calcium works in conjunction with excess glutamate to cause excitotoxicity in your body. More is not always better when it comes to calcium supplementation. Adult females may want to consider Calcium Glucarate as the preferred form of calcium if extra calcium support is indicated. Calcium glucarate may help to pull excess estrogen from your body. This can be useful for older females, especially in conjunction with low dose Indole-3-carbinol, or Broccoli. If hot flashes become an issue, low dose Anxiety Balancing nucleotide blend may be used.
Ehlers Danlos Syndrome Ehlers Danlos Syndrome (EDS) is a condition related to the processing, the production, and the structure of the collagen which is ultimately produced, or the proteins that work in conjunction with that collagen. One of the hallmarks of this condition is extreme hypermobility. A number of individuals with this condition have seen benefits from working on their methylation pathway function. In part, this may be related to studies indicating that matrix metalloproteinases (MMPs) are regulated by methylation (Chernov AV, Strongin AY. 2011;2(3):135-147). MMPs are enzymes that break down collagen. Inadequate methylation may allow increased activity of MMPs secondary to decreased regulation of these enzymes. Basic methylation support includes All in One, Phosphatidyl Serine Complex (PS/PE/PC), DHA and Methylation Support nucleotide blend. You may also consider low dose Methylmate A even before lithium is in balance. Once lithium is shown to be in balance on a HMT, then consider low dose Methylmate B, along with extra B12. In addition to addressing proper methylation cycle function, several additional supplements may be useful for Ehlers Danlos Syndrome. These include low dose Bone Support nucleotide blend and Muscle Support nucleotide blend, as well as supplements that support healthy collagen such as Acute Injury. Supporting natural collagen processing may be particularly helpful for this syndrome.
Psychological conditions related to imbalanced MMP Elevated MMP levels have been associated with psychiatric symptoms. Consult with your own doctor on the use of low dose Bone Support nucleotide blend, TNF nucleotide blend, Inflammatory Pathway Support capsules, General Support nucleotide blend, Cytokine Balance nucleotide blend and Heart Support nucleotide blend. In addition, specific herbs have been reported to be helpful for excess MMP activity, including Polygoni Multiflori Caulis, also known by other names in Traditional Chinese Medicine. Phellodendron amurense and berberine containing herbs such as Goldenseal or barberry have also been used. In addition, extracts of Milk Thistle may be helpful. More traditional medical approaches to excess MMP activity include the use of doxycycline or minocycline. As ALWAYS, work with and defer to your own doctor before using supplementation and/or medication for any health condition.
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Related Tests to Run

Run a HMT, UTM/UEE, and/or FMT to assess your level of toxic metals such as lead and cadmium, as well as your levels of essential minerals, such as strontium and calcium.

A Vitamin D blood spot test may be helpful for assessing any need for additional Vitamin D.


Next Chapter:

Neurotransmitter Test